Abstract
In the present paper, we report the synthesis and the binding profile on 5-HT1A, alpha 1 and D2 receptors of a new series of imide-arylpiperazines 3. The study of the length of the alkyl chain and the imide substructure allows us to suggest some important differences between the no-pharmacophoric sites of both 5-HT1A and alpha 1-adrenergic receptors, which could be of great importance in order to design new selective ligands.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenergic alpha-Antagonists / metabolism
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Animals
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Cerebral Cortex / metabolism
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Corpus Striatum / metabolism
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Dopamine Antagonists / metabolism
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Ligands
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Models, Chemical
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Prazosin / metabolism
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Pyrrolidinones / chemistry*
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Pyrrolidinones / metabolism*
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Raclopride
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Rats
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Receptors, Adrenergic, alpha-1 / metabolism
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Receptors, Dopamine D2 / metabolism
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Receptors, Serotonin / metabolism*
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Receptors, Serotonin, 5-HT1
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Salicylamides / metabolism
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Serotonin Receptor Agonists / chemical synthesis
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Serotonin Receptor Agonists / chemistry*
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Serotonin Receptor Agonists / metabolism*
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Adrenergic alpha-Antagonists
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Dopamine Antagonists
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Ligands
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Pyrrolidinones
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Receptors, Adrenergic, alpha-1
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Receptors, Dopamine D2
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Receptors, Serotonin
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Receptors, Serotonin, 5-HT1
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Salicylamides
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Serotonin Receptor Agonists
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Raclopride
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Prazosin